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Article

Increased palmitoylation of the Gs protein alpha subunit after activation by the beta-adrenergic receptor or cholera toxin.

The Journal of biological chemistry - 15 Nov 1993

Degtyarev M Y, Spiegel A M, Jones T L

Abstract excerpt

The alpha subunit of the heterotrimeric Gs protein that couples the beta-adrenergic receptor to adenylyl cyclase undergoes post-translational palmitoylation. We examined the dynamics of this modification of alpha s by metabolic labeling of COS and S49 lymphoma cells under different conditions. The endogenous alpha s proteins were immunoprecipitated with a peptide-specific antibody, separated by SDS-polyacrylamide...

Topics

Animals
Cells, Cultured
Cholera Toxin
GTP-Binding Proteins
Haplorhini
Lymphoma
Mutation
Palmitic Acid
Palmitic Acids
Protein Processing, Post-Translational
Receptors, Adrenergic, beta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Cells, Cultured

Source

Identifiers

PMID: 8226908

Genes

SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8226908-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Increased palmitoylation of the Gs protein alpha subunit after activation by the beta-adrenergic receptor or cholera toxin.PMID 8226908Read ↗

Reciprocal regulation of Gs alpha by palmitate and the beta gamma subunit.Semantic proximity Read ↗

Palmitoylation of a G protein alpha i subunit requires membrane localization not myristoylation.Semantic proximity Read ↗

Agonist stimulation increases the turnover rate of beta 2AR-bound palmitate and promotes receptor depalmitoylation.Semantic proximity Read ↗

Activation of the alpha subunit of Gs in intact cells alters its abundance, rate of degradation, and membrane avidity.Semantic proximity Read ↗

Activation of an alpha2A-adrenoceptor-Galphao1 fusion protein dynamically regulates the palmitoylation status of the G protein but not of the receptor.Semantic proximity Read ↗

Coordinated agonist regulation of receptor and G protein palmitoylation and functional rescue of palmitoylation-deficient mutants of the G protein G11alpha following fusion to the alpha1b-adrenoreceptor: palmitoylation of G11alpha is not required for interaction with beta*gamma complex.Semantic proximity Read ↗

The palmitoylation status of the G-protein G(o)1 alpha regulates its activity of interaction with the plasma membrane.Semantic proximity Read ↗

DHHC protein-dependent palmitoylation protects regulator of G-protein signaling 4 from proteasome degradation.Semantic proximity Read ↗

Proteasome involvement in the degradation of the G(q) family of Galpha subunits.Semantic proximity Read ↗

S-palmitoylation regulates biogenesis of core glycosylated wild-type and F508del CFTR in a post-ER compartment.Semantic proximity Read ↗

Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway.Semantic proximity Read ↗

The 5-hydroxytryptamine(1A) receptor is stably palmitoylated, and acylation is critical for communication of receptor with Gi protein.Semantic proximity Read ↗

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