Reciprocal regulation of Gs alpha by palmitate and the beta gamma subunit.

doi:10.1073/pnas.93.25.14592

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Article

Reciprocal regulation of Gs alpha by palmitate and the beta gamma subunit.

Proceedings of the National Academy of Sciences of the United States of America - 10 Dec 1996

Iiri T, Backlund P S, Jones T L, Wedegaertner P B, Bourne H R

Abstract excerpt

Hormonal activation of Gs, the stimulatory regulator of adenylyl cyclase, promotes dissociation of alpha s from G beta gamma, accelerates removal of covalently attached palmitate from the G alpha subunit, and triggers release of a fraction of alpha s from the plasma membrane into the cytosol. To...

Topics

Animals
Biological Transport
Cell Line
Cell Membrane
GTP-Binding Protein alpha Subunits, Gs
Mutation
Palmitates
Recombinant Proteins
Signal Transduction

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