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Article

Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesis.

1 Jan 1990

Abstract excerpt

Colonic neoplasia provides an opportunity to study tumor progression because most carcinomas arise from adenomas (polyps), which, in turn, arise from normal epithelia. The malignant potential of adenomas varies with size, histology, and degree of dysplasia. Polyps that are less than 2 cm with villous architecture and severe dysplasia are most likely to contain carcinoma. Previous studies demonstrated that the in...

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Identifiers

PMID: 2105487
DOI: 10.1073/pnas.87.2.558

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