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Article

Phosphorylation of TOPK at Y74, Y272 by Src increases the stability of TOPK and promotes tumorigenesis of colon.

Oncotarget - 26 Apr 2016

Xiao Juanjuan, Duan Qiuhong, Wang Zhe, Yan Wei, Sun Huimin, Xue Peipei, Fan Xiaoming, Zeng Xiaoyu, Chen Juan, Shao Chen, Zhu Feng

Abstract excerpt

T-LAK cell-originated protein kinase (TOPK), a serine/threonine protein kinase, is highly expressed in a variety of tumors and associated with a poor prognosis of human malignancies. However, the activation mechanism of TOPK is still unrevealed. Herein, first we found that Src directly bound with and phosphorylated TOPK at Y74 and Y272 in vitro. Anti-phospho-TOPK at Y74 was prepared, the endogenous...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 27016416
DOI: 10.18632/oncotarget.8231
PMCID: PMC5029716

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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