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Article

The down-regulation of HLA-DM gene expression in rheumatoid arthritis is not related to their promoter polymorphism.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2000

Louis-Plence P, Kerlan-Candon S, Morel J, Combe B, Clot J, Pinet V, Eliaou J F

Abstract excerpt

HLA-DM molecule, a class II-like heterodimer, is a critical factor of HLA class II-dependent Ag presentation. It acts as a molecular chaperone and also functions as a peptide editor favoring the presentation of high-stability peptides. Thus, it appears to skew the peptide repertoire presented to T cells. Variation in HLA-DM expression has considerable effect on Ag presentation and regulation of these genes is...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11046010
DOI: 10.4049/jimmunol.165.9.4861

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The down-regulation of HLA-DM gene expression in rheumatoid arthritis is not related to their promoter polymorphism.PMID 11046010Read ↗

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