Article
The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA reveals an unusual binding mode to Z-DNA.
Proceedings of the National Academy of Sciences of the United States of America - 30 Dec 2008
Ha Sung Chul, Kim Doyoun, Hwang Hye-Yeon, Rich Alexander, Kim Yang-Gyun, Kim Kyeong Kyu
Abstract excerpt
Mammalian DAI (DNA-dependent activator of IFN-regulatory factors), an activator of the innate immune response, senses cytosolic DNA by using 2 N-terminal Z-DNA binding domains (ZBDs) and a third putative DNA binding domain located next to the second ZBD. Compared with other previously known ZBDs, the second ZBD of human DAI (hZbeta(DAI)) shows significant variation in the sequence of the residues that are...
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