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Article

Endogenous elevation of homocysteine induces retinal neuron death in the cystathionine-beta-synthase mutant mouse.

Investigative ophthalmology & visual science - 1 Sept 2009

Ganapathy Preethi S, Moister Brent, Roon Penny, Mysona Barbara A, Duplantier Jennifer, Dun Ying, Moister Tracy K V E, Farley Marlena J, Prasad Puttur D, Liu Kebin, Smith Sylvia B

Abstract excerpt

PURPOSE: To determine the effects of endogenous elevation of homocysteine on the retina using the cystathionine beta-synthase (cbs) mutant mouse. METHODS: Retinal homocysteine in cbs mutant mice was measured by high-performance liquid chromatography (HPLC). Retinal cryosections from cbs(-/-) mice and cbs(+/-) mice were examined for histologic changes by light and electron microscopy. Morphometric analysis was...

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Identifiers

PMID: 19357353
DOI: 10.1167/iovs.09-3402
PMCID: PMC2756015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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