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Article

Absence of a FOXL2 mutation (402C→G) in the blood of adult-type granulosa cell tumor patients possessing the FOXL2 mutation.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society - 1 Nov 2010

Lee Sunyoung, Kim Tae Heon, Won Miae, Ko Jeong-Jae, Rho Jaesook, Lee Kangseok, Bae Jeehyeon

Abstract excerpt

Recently, a new mutation in FOXL2, c.402C→G leading to a p.C134W change, was reported to be found in 97% of adult-type ovarian granulosa cell tumors (GCTs) tested. In the current study, we compared the FOXL2 sequences of genomic DNA isolated from both GCT and blood. Although the GCTs of patients possessed the FOXL2 mutation, their FOXL2 nucleotide sequences of genomic DNA isolated from matching blood samples...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21051974
DOI: 10.1111/IGC.0b013e3181ff3e73

Genes

FOXL2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Absence of a FOXL2 mutation (402C→G) in the blood of adult-type granulosa cell tumor patients possessing the FOXL2 mutation.PMID 21051974Read ↗

Mutation of FOXL2 in granulosa-cell tumors of the ovary.Semantic proximity Read ↗

The specificity of the FOXL2 c.402C>G somatic mutation: a survey of solid tumors.Semantic proximity Read ↗

The FOXL2 mutation (c.402C>G) in adult-type ovarian granulosa cell tumors of three Japanese patients: clinical report and review of the literature.Semantic proximity Read ↗

Adult-Type Granulosa Cell Tumors and FOXL2 MutationSemantic proximity Read ↗

The FOXL2 C134W mutation is characteristic of adult granulosa cell tumors of the ovary.Semantic proximity Read ↗

Adult-type granulosa cell tumor of the ovary: a FOXL2-centric disease.Semantic proximity Read ↗

Mutational Analysis (c.402C>G) of the FOXL2 Gene and Immunohistochemical Expression of the FOXL2 Protein in Testicular Adult Type Granulosa Cell Tumors and Incompletely Differentiated Sex Cord Stromal TumorsSemantic proximity Read ↗

FOXL2 mutations in granulosa cell tumors occurring in males.Semantic proximity Read ↗

Novel FOXL2 Mutation in an Ovarian Adult Granulosa Cell Tumor: Report of a Case With Diagnostic and Clinicopathologic Implications.Semantic proximity Read ↗

Adult ovarian granulosa cell tumor transcriptomics: prevalence of FOXL2 target genes misregulation gives insights into the pathogenic mechanism of the p.Cys134Trp somatic mutation.Semantic proximity Read ↗

Molecular pathogenesis in granulosa cell tumor is not only due to somatic FOXL2 mutation.Semantic proximity Read ↗

Molecular assessment of testicular adult granulosa cell tumor demonstrates significant differences when compared to ovarian counterparts.Semantic proximity Read ↗

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