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Article

The specificity of the FOXL2 c.402C>G somatic mutation: a survey of solid tumors.

PloS one - 24 Nov 2009

Schrader Kasmintan A, Gorbatcheva Bella, Senz Janine, Heravi-Moussavi Alireza, Melnyk Nataliya, Salamanca Clara, Maines-Bandiera Sarah, Cooke Susanna L, Leung Peter, Brenton James D, Gilks C Blake, Monahan John, Huntsman David G

Abstract excerpt

BACKGROUND: A somatic mutation in the FOXL2 gene is reported to be present in almost all (97%; 86/89) morphologically defined, adult-type, granulosa-cell tumors (A-GCTs). This FOXL2 c.402C>G mutation changes a highly conserved cysteine residue to a tryptophan (p.C134W). It was also found in a min...

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Source

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Identifiers

PMID: 19956657
DOI: 10.1371/journal.pone.0007988
PMCID: PMC2777318

Genes

FOXL2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19956657-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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The specificity of the FOXL2 c.402C>G somatic mutation: a survey of solid tumors.PMID 19956657Read ↗

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Adult-Type Granulosa Cell Tumors and FOXL2 MutationSemantic proximity Read ↗

The FOXL2 mutation (c.402C>G) in adult-type ovarian granulosa cell tumors of three Japanese patients: clinical report and review of the literature.Semantic proximity Read ↗

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The C134W (402 C>G) FOXL2 mutation is absent in ovarian gynandroblastoma: insights into the genesis of an unusual tumour.Semantic proximity Read ↗

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Mutational Analysis (c.402C>G) of the FOXL2 Gene and Immunohistochemical Expression of the FOXL2 Protein in Testicular Adult Type Granulosa Cell Tumors and Incompletely Differentiated Sex Cord Stromal TumorsSemantic proximity Read ↗

Detection of FOXL2 C134W Mutation Status by a Novel BaseScope In Situ Hybridization Assay is Highly Sensitive and Specific for Adult Granulosa Cell Tumors.Semantic proximity Read ↗

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