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Article

The FOXL2 mutation (c.402C>G) in adult-type ovarian granulosa cell tumors of three Japanese patients: clinical report and review of the literature.

The Tohoku journal of experimental medicine - 1 Dec 2013

Takahashi Akimasa, Kimura Fuminori, Yamanaka Akiyoshi, Takebayashi Akie, Kita Nobuyuki, Takahashi Kentaro, Murakami Takashi

Abstract excerpt

Adult-type granulosa cell tumor (AGCT) is a rare class of malignant ovarian tumor with unique features, characterized by slow growth, late recurrence, relatively good prognosis and unified cause in almost all patients. The forkhead box L2 (FOXL2) gene encodes an essential transcription factor in the ovary. FOXL2 is important in female sex determination, follicle recruitment, and granulosa cell development. About...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24257635
DOI: 10.1620/tjem.231.243

Genes

FOXL2

Variants

Provenance

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The FOXL2 mutation (c.402C>G) in adult-type ovarian granulosa cell tumors of three Japanese patients: clinical report and review of the literature.PMID 24257635Read ↗

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Impact of FOXL2 mutations on signaling in ovarian granulosa cell tumors.Semantic proximity Read ↗

The FOXL2 C134W mutation is characteristic of adult granulosa cell tumors of the ovary.Semantic proximity Read ↗

The specificity of the FOXL2 c.402C>G somatic mutation: a survey of solid tumors.Semantic proximity Read ↗

Mutational Analysis (c.402C>G) of the FOXL2 Gene and Immunohistochemical Expression of the FOXL2 Protein in Testicular Adult Type Granulosa Cell Tumors and Incompletely Differentiated Sex Cord Stromal TumorsSemantic proximity Read ↗

FOXL2 mutations in granulosa cell tumors occurring in males.Semantic proximity Read ↗

Molecular and pathological analysis of FOXL2 and TERT promoter mutations in adult-type granulosa cell tumors of the ovary: a study of 64 Japanese patients.Semantic proximity Read ↗

Mutational analysis of FOXL2 p.C134W and expression of bone morphogenetic protein 2 in Japanese patients with granulosa cell tumor of ovary.Semantic proximity Read ↗

Absence of a FOXL2 mutation (402C→G) in the blood of adult-type granulosa cell tumor patients possessing the FOXL2 mutation.Semantic proximity Read ↗

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