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Article

IGHV-associated methylation signatures more accurately predict clinical outcomes of chronic lymphocytic leukemia patients than IGHV mutation load.

Haematologica - 1 Apr 2022

Hussmann Dianna, Starnawska Anna, Kristensen Louise, Daugaard Iben, Thomsen Astrid, Kjeldsen Tina E, Hansen Christine Søholm, Bybjerg-Grauholm Jonas, Johansen Karina Dalsgaard, Ludvigsen Maja, Kristensen Thomas, Larsen Thomas Stauffer, Møller Michael Boe, Nyvold Charlotte Guldborg, Hansen Lise Lotte, Wojdacz Tomasz K

Abstract excerpt

Currently, no molecular biomarker indices are used in standard care to make treatment decisions at diagnosis of chronic lymphocytic leukemia (CLL). We used Infinium MethylationEPIC array data from diagnostic blood samples of 114 CLL patients and developed a procedure to stratify patients based on methylation signatures associated with mutation load of the IGHV gene. This procedure allowed us to predict the time...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34092057
DOI: 10.3324/haematol.2021.278477
PMCID: PMC8968906

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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