Article
Ewing tumors that do not overexpress BMI-1 are a distinct molecular subclass with variant biology: a report from the Children's Oncology Group.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2011
Cooper Aaron, van Doorninck John, Ji Lingyun, Russell Darren, Ladanyi Marc, Shimada Hiroyuki, Krailo Mark, Womer Richard B, Hsu Jessie Hao-ru, Thomas Dafydd, Triche Timothy J, Sposto Richard, Lawlor Elizabeth R
Abstract excerpt
PURPOSE: Ewing sarcoma family tumors (ESFT) are aggressive tumors of putative stem cell origin for which prognostic biomarkers and novel treatments are needed. In several human cancers, high expression of the polycomb protein BMI-1 is associated with poor outcome. We have assessed the potential clinical significance of BMI-1 expression level in ESFT. EXPERIMENTAL DESIGN: BMI-1 expression was assessed in 130...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.