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Article

The effect of SNCA 3' region on the levels of SNCA-112 splicing variant.

Neurogenetics - 1 Feb 2011

McCarthy Jeanette J, Linnertz Colton, Saucier Laura, Burke James R, Hulette Christine M, Welsh-Bohmer Kathleen A, Chiba-Falek Ornit

Abstract excerpt

Genetic variability at the 3' region of SNCA locus has been repeatedly associated with susceptibility to sporadic Parkinson's disease (PD). Accumulated evidence emphasizes the importance of SNCA dosage and expression levels in PD pathogenesis. However, the mechanism through which the 3' region of SNCA gene modulates the risk to develop sporadic PD remained elusive. We studied the effect of PD risk-associated...

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Identifiers

PMID: 21046180
DOI: 10.1007/s10048-010-0263-4
PMCID: PMC3030669

Genes

SNCA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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