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Article

Variants in the 3'UTR of SNCA do not affect miRNA-433 binding and alpha-synuclein expression.

European journal of human genetics : EJHG - 1 Dec 2012

Schmitt Ina, Wüllner Ullrich, van Rooyen Jan Pierre, Khazneh Hassan, Becker Julian, Volk Alexander, Kubisch Christian, Becker Tim, Kostic Vladimir S, Klein Christine, Ramirez Alfredo

Abstract excerpt

Alpha-synuclein (SNCA) is a major risk gene for Parkinson's disease (PD) and increased SNCA gene dosage results in a parkinsonian syndrome in affected families. Regulatory regions relevant for SNCA expression include the 3' untranslated region (UTR), which among other regulatory elements contains several micro-RNA-binding sites. Interestingly, variants located in the 3' region of SNCA have been associated with PD...

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Identifiers

PMID: 22617348
DOI: 10.1038/ejhg.2012.84
PMCID: PMC3499742

Genes

SNCA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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