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Article

HPV-16 E6 upregulation of DNMT1 through repression of tumor suppressor p53

26 Oct 2010

Abstract excerpt

The HPV-16 early proteins E6 and E7 are considered to function as oncoproteins in cervical cancer. DNA methyltransferase 1 (DNMT1) is one of the enzymes involved in epigenetic silencing of tumor suppressor genes. In the present study, the functional role and regulation of DNMT1 in HPV-16 E6 associated cervical cancer development were examined. Knockdown of E6 in HPV-16 positive human cervical carcinoma SiHa and...

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Share to Cervical Cancer and HPV Research
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PMID: 21042757
DOI: 10.3892/or_00001023

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