Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HPV16 E6 promotes cell proliferation, migration, and invasion of human cervical cancer cells by elevating both EMT and stemness characteristics

27 Dec 2021

Abstract excerpt

In most cases of cervical cancer, the high risk of the disease is caused by the human papilloma virus (HPV). Surgery or radiation usually benefits patients with early cervical cancer, while the metastatic one is uncurable and new therapeutic strategies and approaches are required. In this study, HPV16 E6 silence or overexpression were carried out to evaluate the possible mechanisms of HPV16 E6 function in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cervical Cancer and HPV Research
Share to Genetic factors in colorectal cancer
Share to Sarcoma Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34957655
DOI: 10.1002/cbin.11756

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HPV16 E6 promotes cell proliferation, migration, and invasion of human cervical cancer cells by elevating both EMT and stemness characteristicsPMID 34957655Read ↗

E6 and E7 Oncoproteins: Potential Targets of Cervical CancerSemantic proximity Read ↗

HPV16 E6-Activated OCT4 Promotes Cervical Cancer Progression by Suppressing p53 Expression via Co-Repressor NCOR1Semantic proximity Read ↗

Expression of HPV-16 E6 Protein and p53 Inactivation Increases the Uterine Cervical Cancer InvasionSemantic proximity Read ↗

Cervical Cancer Stem Cells Selectively Overexpress HPV Oncoprotein E6 that Controls Stemness and Self-Renewal through Upregulation of HES1Semantic proximity Read ↗

Suppression of E6 Oncogene Induces Apoptosis in CaSki Cervical Cancer CellsSemantic proximity Read ↗

HPV16 E6-E7 induces cancer stem-like cells phenotypes in esophageal squamous cell carcinoma through the activation of PI3K/Akt signaling pathway in vitro and in vivo.Semantic proximity Read ↗

The difference of transcriptome of HPV-infected patients contributes more to the occurrence of cervical cancer than the mutations of E6 and E7 genes in HPV16.Semantic proximity Read ↗

HPV16-miRNAs Exert Oncogenic Effects through Enhancers in Human Cervical CancerSemantic proximity Read ↗

Human Papillomavirus E6 and E7: The Cervical Cancer Hallmarks and Targets for TherapySemantic proximity Read ↗

E6 and E7 gene silencing results in decreased methylation of tumor suppressor genes and induces phenotype transformation of human cervical carcinoma cell lines.Semantic proximity Read ↗

Expression of HPV oncogenes from a single integration site in cervical cancer cell linesSemantic proximity Read ↗

HPV-16 E6 upregulation of DNMT1 through repression of tumor suppressor p53Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.