Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

In vitro and in vivo growth suppression of human papillomavirus 16-positive cervical cancer cells by E6 siRNA.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Nov 2003

Yoshinouchi Mitsuo, Yamada Taketo, Kizaki Masahiro, Fen Jin, Koseki Takeyoshi, Ikeda Yasuo, Nishihara Tatsuji, Yamato Kenji

Abstract excerpt

Human papillomavirus type 16 (HPV16), a causative agent of cervical cancers, encodes the E6 and E7 oncogenes, whose simultaneous expression is pivotal for malignant transformation and maintenance of malignant phenotypes. In the hope of developing a gene-specific therapy for HPV-related cancer, we examined the effects of E6 short-interfering RNA (siRNA) on the expression of these oncogenes and on the cell growth...

Topics

Animals
COS Cells
Cell Line
Cell Line, Tumor
Cell Nucleus
Cyclin-Dependent Kinase Inhibitor p21
Cyclins
Female
Humans
In Vitro Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, SCID

Oncogene Proteins, Viral

Phenotype

Phosphorylation

Plasmids

RNA, Messenger

RNA, Small Interfering

Source

Identifiers

PMID: 14599809
DOI: 10.1016/j.ymthe.2003.08.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In vitro and in vivo growth suppression of human papillomavirus 16-positive cervical cancer cells by E6 siRNA.PMID 14599809Read ↗

E6 and E7 gene silencing results in decreased methylation of tumor suppressor genes and induces phenotype transformation of human cervical carcinoma cell lines.Semantic proximity Read ↗

Gene silencing of HPV16 E6/E7 induced by promoter-targeting siRNA in SiHa cellsSemantic proximity Read ↗

Suppression of E6 Oncogene Induces Apoptosis in CaSki Cervical Cancer CellsSemantic proximity Read ↗

Basic mechanisms of high‐risk human papillomavirus‐induced carcinogenesis: Roles of E6 and E7 proteinsSemantic proximity Read ↗

HPV-16 E6 upregulation of DNMT1 through repression of tumor suppressor p53Semantic proximity Read ↗

Antisense targeting human papillomavirus type 16 E6 and E7 genes contributes to apoptosis and senescence in SiHa cervical carcinoma cellsSemantic proximity Read ↗

Growth Suppression Induced by Downregulation of E6-AP Expression in Human Papillomavirus-Positive Cancer Cell Lines Depends on p53Semantic proximity Read ↗

E6 and e7 gene silencing and transformed phenotype of human papillomavirus 16-positive oropharyngeal cancer cells.Semantic proximity Read ↗

Inhibition of cervical cancer cell growth by human papillomavirus virus–like particles packaged with human papillomavirus oncoprotein short hairpin RNAsSemantic proximity Read ↗

Disruption of HPV16-E7 by CRISPR/Cas System Induces Apoptosis and Growth Inhibition in HPV16 Positive Human Cervical Cancer CellsSemantic proximity Read ↗

CRISPR/Cas9-based inactivation of human papillomavirus oncogenes E6 or E7 induces senescence in cervical cancer cellsSemantic proximity Read ↗

Human papillomavirus 16E6/E7 activates autophagy via Atg9B and LAMP1 in cervical cancer cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.