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Article

Mutation of Ser172 in yeast β tubulin induces defects in microtubule dynamics and cell division.

PloS one - 21 Oct 2010

Caudron Fabrice, Denarier Eric, Thibout-Quintana Jenny-Constanza, Brocard Jacques, Andrieux Annie, Fourest-Lieuvin Anne

Abstract excerpt

Ser172 of β tubulin is an important residue that is mutated in a human brain disease and phosphorylated by the cyclin-dependent kinase Cdk1 in mammalian cells. To examine the role of this residue, we used the yeast S. cerevisiae as a model and produced two different mutations (S172A and S172E) of the conserved Ser172 in the yeast β tubulin Tub2p. The two mutants showed impaired cell growth on benomyl-containing...

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Identifiers

PMID: 21042413
DOI: 10.1371/journal.pone.0013553
PMCID: PMC2958848

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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