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Article

Modulation of tubulin polypeptide ratios by the yeast protein Pac10p.

Genetics - 1 Jun 1998

Alvarez P, Smith A, Fleming J, Solomon F

Abstract excerpt

Normal assembly and function of microtubules require maintenance of the proper levels of several proteins, including the tubulin polypeptides themselves. For example, in yeast a significant excess of beta-tubulin causes rapid microtubule disassembly and subsequent cell death. Even the modest excess of beta-tubulin produced by genetic alterations such as deletion of the minor alpha-tubulin gene TUB3 affects cell...

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Identifiers

PMID: 9611197
DOI: 10.1093/genetics/149.2.857
PMCID: PMC1460170

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