Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Suppression of the malignant phenotype in human pancreatic cancer cells by the overexpression of manganese superoxide dismutase.

Molecular cancer therapeutics - 1 Apr 2003

Weydert Christine, Roling Benjamin, Liu Jingru, Hinkhouse Marilyn M, Ritchie Justine M, Oberley Larry W, Cullen Joseph J

Abstract excerpt

Cells contain a large number of antioxidants to prevent or repair the damage caused by reactive oxygen species. One component of the antioxidant system, manganese superoxide dismutase (MnSOD), is localized in the mitochondria, and the levels of this protein have been previously shown to inversely correlate with pancreatic cancer cell growth. The aim of the present study was to determine whether MnSOD...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviridae
Share to Agar

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Antioxidants

Share to Densitometry

Share to Gene Transfer Techniques

Share to Mice, Nude

Share to Neoplasm Transplantation

Share to Superoxide Dismutase

Source

Identifiers

PMID: 12700280

Genes

MIA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Suppression of the malignant phenotype in human pancreatic cancer cells by the overexpression of manganese superoxide dismutase.PMID 12700280Read ↗

Redox regulation of pancreatic cancer cell growth: role of glutathione peroxidase in the suppression of the malignant phenotype.Semantic proximity Read ↗

Suppression of the malignant phenotype in pancreatic cancer by overexpression of phospholipid hydroperoxide glutathione peroxidase.Semantic proximity Read ↗

Adenovirus-mediated manganese superoxide dismutase gene transfer to hamster cheek pouch carcinoma cells.Semantic proximity Read ↗

Alteration of cellular phenotype and responses to oxidative stress by manganese superoxide dismutase and a superoxide dismutase mimic in RWPE-2 human prostate adenocarcinoma cells.Semantic proximity Read ↗

Podoplanin overexpression in human mesothelioma cell lines enhances the tumorigenic phenotype.Semantic proximity Read ↗

MnSOD up-regulates maspin tumor suppressor gene expression in human breast and prostate cancer cells.Semantic proximity Read ↗

Role of Rac1-dependent NADPH oxidase in the growth of pancreatic cancer.Semantic proximity Read ↗

Phenotypic changes induced in human breast cancer cells by overexpression of manganese-containing superoxide dismutase.Semantic proximity Read ↗

Suppression of radiation‐induced neoplastic transformation by overexpression of mitochondrial superoxide dismutaseSemantic proximity Read ↗

Manganese-containing superoxide dismutase overexpression causes phenotypic reversion in SV40-transformed human lung fibroblasts.Semantic proximity Read ↗

Overexpression of manganese superoxide dismutase in DU145 human prostate carcinoma cells has multiple effects on cell phenotype.Semantic proximity Read ↗

Tumor suppressive effects of MnSOD overexpression may involve imbalance in peroxide generation versus peroxide removal.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.