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Article

Sequential activation of phosphatidylinositol 3-kinase, beta Pix, Rac1, and Nox1 in growth factor-induced production of H2O2.

Molecular and cellular biology - 1 May 2004

Park Hye Sun, Lee Seung Hye, Park Dongeun, Lee Jun Sung, Ryu Sung Ho, Lee Won Jae, Rhee Sue Goo, Bae Yun Soo

Abstract excerpt

The generation of reactive oxygen species (ROS) in cells stimulated with growth factors requires the activation of phosphatidylinositol 3-kinase (PI3K) and the Rac protein. We report here that the COOH-terminal region of Nox1, a protein related to gp91(phox) (Nox2) of phagocytic cells, is constitutively associated with beta Pix, a guanine nucleotide exchange factor for Rac. Both growth factor-induced ROS...

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Identifiers

PMID: 15121857
DOI: 10.1128/MCB.24.10.4384-4394.2004
PMCID: PMC400450

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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