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Article

Regulation of pancreatic cancer growth by superoxide

5 Mar 2012

Abstract excerpt

K-ras mutations have been identified in up to 95% of pancreatic cancers, implying their critical role in the molecular pathogenesis. Expression of K-ras oncogene in an immortalized human pancreatic ductal epithelial cell line, originally derived from normal pancreas (H6c7), induced the formation of carcinoma in mice. We hypothesized that K-ras oncogene correlates with increased non-mitochondrial-generated...

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Share to Cancer, Hypoxia, and Metabolism
Share to Nitric Oxide and Endothelin Effects
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PMID: 22392697
DOI: 10.1002/mc.21891

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