Article
Treatment of pancreatic cancer cells with dicumarol induces cytotoxicity and oxidative stress.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2004
Lewis Anne, Ough Matthew, Li Ling, Hinkhouse Marilyn M, Ritchie Justine M, Spitz Douglas R, Cullen Joseph J
Abstract excerpt
PURPOSE: NAD(P)H: quinone oxidoreductase (NQO(1)) catalyzes the two-electron reduction of quinones to hydroquinones. This reaction is believed to prevent the one-electron reduction of quinones that would result in redox cycling with generation of superoxide (O(2)(.-)). We have recently demonstrated that inhibition of NQO(1) with dicumarol increases intracellular O(2)(.-) production and inhibits the in vitro...
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