Article
Dbf4 regulates the Cdc5 Polo-like kinase through a distinct non-canonical binding interaction.
The Journal of biological chemistry - 31 Dec 2010
Chen Ying-Chou, Weinreich Michael
Abstract excerpt
Cdc7-Dbf4 is a conserved, two-subunit kinase required for initiating eukaryotic DNA replication. Recent studies have shown that Cdc7-Dbf4 also regulates the mitotic exit network (MEN) and monopolar homolog orientation in meiosis I (Matos, J., Lipp, J. J., Bogdanova, A., Guillot, S., Okaz, E., Junqueira, M., Shevchenko, A., and Zachariae, W. (2008) Cell 135, 662-678 and Miller, C. T., Gabrielse, C., Chen, Y. C.,...
Topics
- Animals
- Cell Cycle
- Cell Cycle Proteins
- DNA Replication
- Gene Deletion
- Genotype
- Humans
- Mice
- Microtubules
- Mutation
- Protein Binding
- Protein Kinases