Article
A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration.
Chemistry & biology - 1 Nov 2007
Snead Jennifer L, Sullivan Matthew, Lowery Drew M, Cohen Michael S, Zhang Chao, Randle David H, Taunton Jack, Yaffe Michael B, Morgan David O, Shokat Kevan M
Abstract excerpt
Protein phosphorylation is a ubiquitous mechanism for cellular signal propagation, and signaling network complexity presents a challenge to protein kinase substrate identification. Few targets of Polo-like kinases are known, despite their significant role in coordinating cell-cycle progression. Here, we combine chemical-genetic, bioinformatic, and proteomic tools for Polo-like kinase substrate identification....
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