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Article

Structural and functional analysis of SMAD4 gene promoter in malignant pancreatic and colorectal tissues: detection of two novel polymorphic nucleotide repeats.

Cancer epidemiology - 1 Jun 2011

Nikolic Aleksandra, Kojic Snezana, Knezevic Srbislav, Krivokapic Zoran, Ristanovic Momcilo, Radojkovic Dragica

Abstract excerpt

BACKGROUND: The tumor suppressor gene SMAD4 (DPC4) encodes for the common intracellular mediator of the TGF-β superfamily pathway, which regulates numerous cellular processes, such as cell proliferation, cell differentiation, apoptosis, cell fate and migration. This study was aimed to investigate the presence of genetic variants in SMAD4 gene promoter in malignant pancreatic and colorectal tissue and to analyze...

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Source

Identifiers

PMID: 21036691
DOI: 10.1016/j.canep.2010.10.002

Genes

SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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