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Article

Genetic association of MMP14 promoter variants and their functional significance in gallbladder cancer pathogenesis.

Journal of human genetics - 1 Oct 2021

J Vinay, Mishra Debakanta, Meher Dinesh, Dash Sashibhusan, Besra Kusumbati, Pattnaik Niharika, Singh Shivaram Prasad, Dixit Manjusha

Abstract excerpt

Gallbladder cancer (GBC) is relatively rare but shows high frequency in certain geographical regions and ethnic groups, which include Northern and Eastern states of India. Previous studies in India have indicated the possible role of genetic predisposition in GBC pathogenesis. Although matrix metalloproteinase-14 (MMP14) is known modulator of tumour microenvironment and tumorigenesis and TCGA data also suggests...

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PMID: 33727629
DOI: 10.1038/s10038-021-00917-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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