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Article

Promoter‐wide analysis of Smad4 binding sites in human epithelial cells

24 Jul 2009

Abstract excerpt

Smad4, the common partner Smad, is a key molecule in transforming growth factor-beta (TGF-beta) family signaling. Loss of Smad4 expression is found in several types of cancer, including pancreatic cancer and colon cancer, and is related to carcinogenesis. Here we identified Smad4 binding sites in the promoter regions of over 25 500 known genes by chromatin immunoprecipitation on a microarray (ChIP-chip) in HaCaT...

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Identifiers

PMID: 19686287
DOI: 10.1111/j.1349-7006.2009.01299.x

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