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Methylation of the SPARC gene promoter and its clinical implication in pancreatic cancer

26 Mar 2010

Abstract excerpt

BACKGROUND: The secreted protein acidic and rich in cysteine (SPARC) plays a pivotal role in regulating cell-matrix interactions and tumor angiogenesis, proliferation, and migration. Detection of SPARC gene methylation may be useful as a tumorigenesis marker for early detection of pancreatic cancer. METHODS: Methylation of the SPARC gene transcriptional regulation region (TRR) was detected using...

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PMID: 20338068
DOI: 10.1186/1756-9966-29-28

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