Article
The impact of PTEN regulation by CK2 on PI3K-dependent signaling and leukemia cell survival.
Advances in enzyme regulation - 1 Jan 2011
Barata João T
Abstract excerpt
Gene alterations affecting elements of PI3K signaling pathway do not appear to be sufficient to explain the extremely high frequency of PI3K signaling hyperactivation in leukemia. It has been known for long that PTEN phosphorylation at the C-terminal tail, in particular by CK2, contributes to the...
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