Article
DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells.
The Journal of biological chemistry - 2 Jan 2012
Li Yi, Martin Brent R, Cravatt Benjamin F, Hofmann Sandra L
Abstract excerpt
Post-translational palmitoylation of intracellular proteins is mediated by protein palmitoyltransferases belonging to the DHHC family, which share a common catalytic Asp-His-His-Cys (DHHC) motif. Several members have been implicated in neuronal development, neurotransmission, and synaptic plasticity. We previously observed that mice homozygous for a hypomorphic allele of the ZDHHC5 gene are impaired in...
Topics
- Acyltransferases
- Animals
- Cell Differentiation
- Cells, Cultured
- Humans
- Lipoylation
- Membrane Proteins
- Mice
- Mutagenesis, Site-Directed
- Mutation
- Neural Stem Cells
- Neurons
- Protein Multimerization
- Protein Structure, Quaternary