Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells.

The Journal of biological chemistry - 2 Jan 2012

Li Yi, Martin Brent R, Cravatt Benjamin F, Hofmann Sandra L

Abstract excerpt

Post-translational palmitoylation of intracellular proteins is mediated by protein palmitoyltransferases belonging to the DHHC family, which share a common catalytic Asp-His-His-Cys (DHHC) motif. Several members have been implicated in neuronal development, neurotransmission, and synaptic plasticity. We previously observed that mice homozygous for a hypomorphic allele of the ZDHHC5 gene are impaired in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acyltransferases
Share to Lipoylation
Share to Mutagenesis, Site-Directed

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Neural Stem Cells

Share to Neurons

Share to Protein Multimerization

Share to Protein Structure, Quaternary

Share to Proteolysis

Source

Open in PubMed Open full text

Identifiers

PMID: 22081607
DOI: 10.1074/jbc.M111.306183
PMCID: PMC3249106

Genes

ZDHHC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells.PMID 22081607Read ↗

Snx14 proximity labeling reveals a role in saturated fatty acid metabolism and ER homeostasis defective in SCAR20 diseaseSemantic proximity Read ↗

Curation of the Mammalian Palmitoylome Indicates a Pivotal Role for Palmitoylation in Diseases and Disorders of the Nervous System and CancersSemantic proximity Read ↗

DHHC protein-dependent palmitoylation protects regulator of G-protein signaling 4 from proteasome degradation.Semantic proximity Read ↗

Zdhhc13-dependent Drp1 S-palmitoylation impacts brain bioenergetics, anxiety, coordination and motor skills.Semantic proximity Read ↗

Inhibition of DHHC20-Mediated EGFR Palmitoylation Creates a Dependence on EGFR Signaling.Semantic proximity Read ↗

Altered lipid homeostasis underlies selective neurodegeneration in SNX14 deficiencySemantic proximity Read ↗

The S-palmitoylome and DHHC-PAT interactome of <i>Drosophila melanogaster</i> S2R+ cells indicate a high degree of conservation to mammalian palmitoylomesSemantic proximity Read ↗

Deciphering the protein dynamics and molecular determinants of iPSC-derived neuronsSemantic proximity Read ↗

Micro-Scale Control of Oligodendrocyte Morphology and Myelination by the Intellectual Disability-Linked Protein Acyltransferase ZDHHC9Semantic proximity Read ↗

Mice with alopecia, osteoporosis, and systemic amyloidosis due to mutation in Zdhhc13, a gene coding for palmitoyl acyltransferase.Semantic proximity Read ↗

Palmitoylation and membrane interactions of the neuroprotective chaperone cysteine-string protein.Semantic proximity Read ↗

1-Deoxysphingolipids Require Very-Long-Chain Ceramide Synthesis to Induce ER Stress and NeurotoxicitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.