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Article

Suppression of APP-containing vesicle trafficking and production of beta-amyloid by AID/DHHC-12 protein.

Journal of neurochemistry - 1 Dec 2009

Mizumaru Chie, Saito Yuhki, Ishikawa Takao, Yoshida Tomohiro, Yamamoto Tohru, Nakaya Tadashi, Suzuki Toshiharu

Abstract excerpt

The metabolism of amyloid beta-protein precursor (APP) is regulated by various cytoplasmic and/or membrane-associated proteins, some of which are involved in the regulation of intracellular membrane trafficking. We found that a protein containing Asp-His-His-Cys (DHHC) domain, alcadein and APP interacting DHHC protein (AID)/DHHC-12, strongly inhibited APP metabolism, including amyloid beta-protein (Abeta)...

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Source

Identifiers

PMID: 19780898
DOI: 10.1111/j.1471-4159.2009.06399.x

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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