Article
Large replication study and meta-analyses of DVWA as an osteoarthritis susceptibility locus in European and Asian populations.
Human molecular genetics - 15 Apr 2009
Meulenbelt Ingrid, Chapman Kay, Dieguez-Gonzalez Rebeca, Shi Dongquan, Tsezou Aspasia, Dai Jin, Malizos Konstantinos N, Kloppenburg Margreet, Carr Andrew, Nakajima Masahiro, van der Breggen Ruud, Lakenberg Nico, Gomez-Reino Juan J, Jiang Qing, Ikegawa Shiro, Gonzalez Antonio, Loughlin John, Slagboom Eline P
Abstract excerpt
Recently, through a genome wide association study in Japanese knee osteoarthritis (OA) cases, a previously unknown gene, DVWA, was identified. The non-synonymous single nucleotide polymorphism (SNP) rs7639618 was subsequently found to be consistent and most significantly associated in Japanese and Han Chinese knee OA studies and functional relevant. Here, the association of the DVWA polymorphisms (rs7639618,...
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