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Article

Synergism between DNA methylation and macroH2A1 occupancy in epigenetic silencing of the tumor suppressor gene p16(CDKN2A).

Nucleic acids research - 1 Mar 2011

Barzily-Rokni Michal, Friedman Nathalie, Ron-Bigger Shulamit, Isaac Sara, Michlin Dan, Eden Amir

Abstract excerpt

Promoter hypermethylation and heterochromatinization is a frequent event leading to gene inactivation and tumorigenesis. At the molecular level, inactivation of tumor suppressor genes in cancer has many similarities to the inactive X chromosome in female cells and is defined and maintained by DNA methylation and characteristic histone modifications. In addition, the inactive-X is marked by the histone macroH2A, a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21030442
DOI: 10.1093/nar/gkq994
PMCID: PMC3045621

Genes

MLH1

Provenance

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