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Article

Iron-binding activity in yeast frataxin entails a trade off with stability in the alpha1/beta1 acidic ridge region.

The Biochemical journal - 9 Feb 2010

Correia Ana R, Wang Tao, Craig Elizabeth A, Gomes Cláudio M

Abstract excerpt

Frataxin is a highly conserved mitochondrial protein whose deficiency in humans results in Friedreich's ataxia (FRDA), an autosomal recessive disorder characterized by progressive ataxia and cardiomyopathy. Although its cellular function is still not fully clear, the fact that frataxin plays a cr...

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Identifiers

PMID: 20001966
DOI: 10.1042/BJ20091612
PMCID: PMC2819628

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20001966-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Iron-binding activity in yeast frataxin entails a trade off with stability in the alpha1/beta1 acidic ridge region.PMID 20001966Read ↗

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