Article
Naked dense bodies provoke depression.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 27 Oct 2010
Hallermann Stefan, Kittel Robert J, Wichmann Carolin, Weyhersmüller Annika, Fouquet Wernher, Mertel Sara, Owald David, Eimer Stefan, Depner Harald, Schwärzel Martin, Sigrist Stephan J, Heckmann Manfred
Abstract excerpt
At presynaptic active zones (AZs), the frequently observed tethering of synaptic vesicles to an electron-dense cytomatrix represents a process of largely unknown functional significance. Here, we identified a hypomorphic allele, brpnude, lacking merely the last 1% of the C-terminal amino acids (17 of 1740) of the active zone protein Bruchpilot. In brpnude, electron-dense bodies were properly shaped, though...
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