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Article

PRRT2: from Paroxysmal Disorders to Regulation of Synaptic Function.

Trends in neurosciences - 1 Oct 2016

Valtorta Flavia, Benfenati Fabio, Zara Federico, Meldolesi Jacopo

Abstract excerpt

In the past few years, proline-rich transmembrane protein (PRRT)2 has been identified as the causative gene for several paroxysmal neurological disorders. Recently, an important role of PRRT2 in synapse development and function has emerged. Knock down of the protein strongly impairs the formation of synaptic contacts and neurotransmitter release. At the nerve terminal, PRRT2 endows synaptic vesicle exocytosis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27624551
DOI: 10.1016/j.tins.2016.08.005

Genes

PRRT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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