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Article

Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage.

Nucleic acids research - 1 Oct 2008

Sabouri Nasim, Viberg Jörgen, Goyal Dinesh Kumar, Johansson Erik, Chabes Andrei

Abstract excerpt

The enzyme ribonucleotide reductase, responsible for the synthesis of deoxyribonucleotides (dNTP), is upregulated in response to DNA damage in all organisms. In Saccharomyces cerevisiae, dNTP concentration increases approximately 6- to 8-fold in response to DNA damage. This concentration increase is associated with improved tolerance of DNA damage, suggesting that translesion DNA synthesis is more efficient at...

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Identifiers

PMID: 18772226
DOI: 10.1093/nar/gkn555
PMCID: PMC2553575

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage.PMID 18772226Read ↗

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The DNA polymerase activity of Saccharomyces cerevisiae Rev1 is biologically significant.Semantic proximity Read ↗

How DNA lesions are turned into mutations within cells?Semantic proximity Read ↗

Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype.Semantic proximity Read ↗

A switch between DNA polymerases δ and λ promotes error-free bypass of 8-oxo-G lesionsSemantic proximity Read ↗

Participation of DNA polymerase zeta in replication of undamaged DNA in Saccharomyces cerevisiae.Semantic proximity Read ↗

DNA repair: Polymerases for passing lesions.Semantic proximity Read ↗

Ribonucleotide incorporation by yeast DNA polymerase ζ.Semantic proximity Read ↗

The polymerase eta translesion synthesis DNA polymerase acts independently of the mismatch repair system to limit mutagenesis caused by 7,8-dihydro-8-oxoguanine in yeast.Semantic proximity Read ↗

Mechanisms of mutagenesis: DNA replication in the presence of DNA damage.Semantic proximity Read ↗

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