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Article

A Comprehensive Review of Mutations in the MERTK Proto-Oncogene.

Advances in experimental medicine and biology - 1 Jan 2016

Parinot Célia, Nandrot Emeline F

Abstract excerpt

Phagocytosis and elimination of shed aged photoreceptor outer segments (POS) by retinal pigment epithelial cells is crucial for photoreceptor function and survival. Genetic studies on a natural animal model of recessive retinal degeneration allowed the identification of MerTK, the gene encoding the surface receptor required for POS internalization. Following this discovery, screenings of DNA samples from patients...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26427420
DOI: 10.1007/978-3-319-17121-0_35

Genes

MERTK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A Comprehensive Review of Mutations in the MERTK Proto-Oncogene.PMID 26427420Read ↗

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Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosaSemantic proximity Read ↗

Retinal Degeneration Secondary to MERTK Mutations: Potential Candidate for Gene Therapy.Semantic proximity Read ↗

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