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Article

Inferring PDZ domain multi-mutant binding preferences from single-mutant data.

PloS one - 30 Sept 2010

Zaslavsky Elena, Bradley Philip, Yanover Chen

Abstract excerpt

Many important cellular protein interactions are mediated by peptide recognition domains. The ability to predict a domain's binding specificity directly from its primary sequence is essential to understanding the complexity of protein-protein interaction networks. One such recognition domain is the PDZ domain, functioning in scaffold proteins that facilitate formation of signaling networks. Predicting the PDZ...

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Identifiers

PMID: 20976110
DOI: 10.1371/journal.pone.0012787
PMCID: PMC2956758

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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