Article
A regression framework incorporating quantitative and negative interaction data improves quantitative prediction of PDZ domain-peptide interaction from primary sequence.
Bioinformatics (Oxford, England) - 1 Feb 2011
Shao Xiaojian, Tan Chris S H, Voss Courtney, Li Shawn S C, Deng Naiyang, Bader Gary D
Abstract excerpt
MOTIVATION: Predicting protein interactions involving peptide recognition domains is essential for understanding the many important biological processes they mediate. It is important to consider the binding strength of these interactions to help us construct more biologically relevant protein interaction networks that consider cellular context and competition between potential binders. RESULTS: We developed a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.