Article

A Novel Computational Framework to Predict the Impact of a Point Mutation on PDZ Domain Classification

2018-01-07

Abstract excerpt

PDZ domains represent one of the most common protein homology regions playing key roles in several diseases. Point mutations (PM) in amino acid primary sequence of PDZ domains can alter domain functions by affecting for example, downstream phosphorylation, a pivotal process in biology. Our goal in this present study was to introduce a novel approach to investigate how point mutations within the Class 1, Class 2 an...

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Identifiers and source

Literature Corpus work: 59d7fb89-579a-5457-a8de-a886e6a75908
DOI: 10.1101/244251

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