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Identification of a Genetic Locus Responsible for Antimicrobial Peptide Resistance in Clostridium difficile

26 Oct 2010

Abstract excerpt

Clostridium difficile causes chronic intestinal disease, yet little is understood about how the bacterium interacts with and survives in the host. To colonize the intestine and cause persistent disease, the bacterium must circumvent killing by host innate immune factors, such as cationic antimicrobial peptides (CAMPs). In this study, we investigated the effect of model CAMPs on growth and found that C. difficile...

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PMID: 20974818
DOI: 10.1128/iai.00731-10

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