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The C. difficile clnRAB operon initiates adaptations to the host environment in response to LL-37

20 Aug 2018

Abstract excerpt

To cause disease, Clostridioides (Clostridium) difficile must resist killing by innate immune effectors in the intestine, including the host antimicrobial peptide, cathelicidin (LL-37). The mechanisms that enable C. difficile to adapt to the intestine in the presence of antimicrobial peptides are unknown. Expression analyses revealed an operon, CD630_16170-CD630_16190 (clnRAB), which is highly induced by LL-37...

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PMID: 30125334
DOI: 10.1371/journal.ppat.1007153

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