Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of pathways to high-level vancomycin resistance in Clostridioides difficile that incur high fitness costs in key pathogenicity traits.

PLoS biology - 1 Aug 2024

Buddle Jessica E, Thompson Lucy M, Williams Anne S, Wright Rosanna C T, Durham William M, Turner Claire E, Chaudhuri Roy R, Brockhurst Michael A, Fagan Robert P

Abstract excerpt

Clostridioides difficile is an important human pathogen, for which there are very limited treatment options, primarily the glycopeptide antibiotic vancomycin. In recent years, vancomycin resistance has emerged as a serious problem in several gram-positive pathogens, but high-level resistance has yet to be reported for C. difficile, although it is not known if this is due to constraints upon resistance evolution...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Bacterial Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Clostridioides difficile

Share to Gene Expression Regulation, Bacterial

Share to Genetic Fitness

Share to Spores, Bacterial

Share to Vancomycin

Share to Vancomycin Resistance

Source

Open in PubMed Open full text

Identifiers

PMID: 39146240
DOI: 10.1371/journal.pbio.3002741
PMCID: PMC11326576

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of pathways to high-level vancomycin resistance in Clostridioides difficile that incur high fitness costs in key pathogenicity traits.PMID 39146240Read ↗

Multiple evolutionary pathways lead to vancomycin resistance in <i>Clostridioides difficile</i>Semantic proximity Read ↗

Constitutive expression of the cryptic vanGCd operon promotes vancomycin resistance in Clostridioides difficile clinical isolatesSemantic proximity Read ↗

Pathogenicity and virulence of Clostridioides difficileSemantic proximity Read ↗

Molecular mechanisms of vancomycin resistanceSemantic proximity Read ↗

Acquisition of Daptomycin Resistance by Enterococcus faecium Confers Collateral Sensitivity to GlycopeptidesSemantic proximity Read ↗

Large-scale screening of a targeted Enterococcus faecalis mutant library identifies envelope fitness factors.Semantic proximity Read ↗

Identification of a Genetic Locus Responsible for Antimicrobial Peptide Resistance in Clostridium difficileSemantic proximity Read ↗

Accessory Gene Regulator-1 Locus Is Essential for Virulence and Pathogenesis of Clostridium difficileSemantic proximity Read ↗

In vitro selection, via serial passage, of Clostridium difficile mutants with reduced susceptibility to fidaxomicin or vancomycin.Semantic proximity Read ↗

Clostridioides difficile as a Dynamic Vehicle for the Dissemination of Antimicrobial-Resistance Determinants: Review and In Silico AnalysisSemantic proximity Read ↗

Preliminary analysis of the genetic basis for vancomycin resistance in Staphylococcus aureus strain Mu50.Semantic proximity Read ↗

Chromosomal Resistance to Metronidazole in Clostridioides difficile Can Be Mediated by Epistasis between Iron Homeostasis and OxidoreductasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.