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Article

Th2 LCR is essential for regulation of Th2 cytokine genes and for pathogenesis of allergic asthma

18 May 2010

Abstract excerpt

Previous studies have shown that Th2 cytokine genes on mouse chromosome 11 are coordinately regulated by the Th2 locus control region (LCR). To examine the in vivo function of Th2 LCR, we generated CD4-specific Th2 LCR-deficient (cLCR KO) mice using Cre-LoxP recombination. The number of CD4 T cells in the cLCR KO mouse was comparable to that in wild-type mice. The expression of Th2 cytokines was dramatically...

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PMID: 20483988
DOI: 10.1073/pnas.1005383107

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