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Article

Crucial function of histone deacetylase 1 for differentiation of teratomas in mice and humans.

The EMBO journal - 1 Dec 2010

Lagger Sabine, Meunier Dominique, Mikula Mario, Brunmeir Reinhard, Schlederer Michaela, Artaker Matthias, Pusch Oliver, Egger Gerda, Hagelkruys Astrid, Mikulits Wolfgang, Weitzer Georg, Muellner Ernst W, Susani Martin, Kenner Lukas, Seiser Christian

Abstract excerpt

Histone deacetylase (HDAC) inhibitors induce cell cycle arrest, differentiation or apoptosis in tumour cells and are, therefore, promising anti-cancer reagents. However, the specific HDAC isoforms that mediate these effects are not yet identified. To explore the role of HDAC1 in tumourigenesis and tumour proliferation, we established an experimental teratoma model using wild-type and HDAC1-deficient embryonic...

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Identifiers

PMID: 20967026
DOI: 10.1038/emboj.2010.264
PMCID: PMC3020644

Genes

HDAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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