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Article

A Cys-loop mutation in the Caenorhabditis elegans nicotinic receptor subunit UNC-63 impairs but does not abolish channel function.

The Journal of biological chemistry - 28 Jan 2011

Jones Andrew K, Rayes Diego, Al-Diwani Adam, Maynard Thomas P R, Jones Rachel, Hernando Guillermina, Buckingham Steven D, Bouzat Cecilia, Sattelle David B

Abstract excerpt

The nematode Caenorhabditis elegans is an established model organism for studying neurobiology. UNC-63 is a C. elegans nicotinic acetylcholine receptor (nAChR) α-subunit. It is an essential component of the levamisole-sensitive muscle nAChR (L-nAChR) and therefore plays an important role in cholinergic transmission at the nematode neuromuscular junction. Here, we show that worms with the unc-63(x26) allele, with...

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Identifiers

PMID: 20966081
DOI: 10.1074/jbc.M110.177238
PMCID: PMC3024750

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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