Article
A neuronal acetylcholine receptor regulates the balance of muscle excitation and inhibition in Caenorhabditis elegans.
PLoS biology - 1 Dec 2009
Jospin Maelle, Qi Yingchuan B, Stawicki Tamara M, Boulin Thomas, Schuske Kim R, Horvitz H Robert, Bessereau Jean-Louis, Jorgensen Erik M, Jin Yishi
Abstract excerpt
In the nematode Caenorhabditis elegans, cholinergic motor neurons stimulate muscle contraction as well as activate GABAergic motor neurons that inhibit contraction of the contralateral muscles. Here, we describe the composition of an ionotropic acetylcholine receptor that is required to maintain excitation of the cholinergic motor neurons. We identified a gain-of-function mutation that leads to spontaneous muscle...
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