Article
Muscular dystrophy associated mutations in caveolin-1 induce neurotransmission and locomotion defects in Caenorhabditis elegans.
Invertebrate neuroscience : IN - 1 Sept 2007
Parker Scott, Peterkin Helen S, Baylis Howard A
Abstract excerpt
Mutations in human caveolin-3 are known to underlie a range of myopathies. The cav-1 gene of Caenorhabditis elegans is a homologue of human caveolin-3 and is expressed in both neurons and body wall muscles. Within the body wall muscle CAV-1 localises adjacent to neurons, most likely at the neuromuscular junction (NMJ). Using fluorescently tagged CAV-1 and pre- and post-synaptic markers we demonstrate that CAV-1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
